Zito J, Fitzpatrick P, Amedee R
Department of Otolaryngology-Head and Neck Surgery at Tulane University Health Sciences Center, New Orleans, Louisiana, USA.
J La State Med Soc. 2001 Aug;153(8):395-8.
Juvenile nasopharyngeal angiofibroma is a rare yet potentially destructive vascular tumor that typically affects adolescent males. While the etiology of these tumors remains unknown, great advances have been made in their diagnosis and treatment. When juvenile nasopharyngeal angiofibroma is diagnosed at an early stage, the prognosis is generally very good, as patients can be treated with a combination of pre-operative embolization and surgical resection. Advanced juvenile nasopharyngeal angiofibroma is much more difficult to treat, since orbital and intracranial involvement are common in the natural progression of the disease. However, due to the rather innocuous presenting symptoms (commonly, nasal obstruction and epistaxis), diagnosis most often occurs in the later stages of the disease. For this reason, it is important for all physicians to have a high degree of suspicion for juvenile nasopharyngeal angiofibroma when evaluating a male adolescent with these symptoms.
青少年鼻咽血管纤维瘤是一种罕见但具有潜在破坏性的血管肿瘤，通常影响青春期男性。虽然这些肿瘤的病因尚不清楚，但在其诊断和治疗方面已取得了很大进展。当青少年鼻咽血管纤维瘤在早期被诊断出来时，预后通常非常好，因为患者可以接受术前栓塞和手术切除相结合的治疗。晚期青少年鼻咽血管纤维瘤治疗起来要困难得多，因为在疾病的自然发展过程中，眼眶和颅内受累很常见。然而，由于其表现症状相当隐匿（通常为鼻塞和鼻出血），诊断大多发生在疾病的后期。因此，所有医生在评估有这些症状的男性青少年时，对青少年鼻咽血管纤维瘤要有高度的怀疑，这一点很重要。
