Curtis J J, Clark N C, McKenney C A, Walls J T, Schmaltz R A, Demmy T L, Jones J W, Wilson W R, Wagner-Mann C C
Department of Cardiothoracic Surgery, University of Missouri, Columbia, USA.
Ann Thorac Surg. 2001 Sep;72(3):731-4. doi: 10.1016/s0003-4975(01)02835-1.
We studied whether tracheostomy after coronary artery bypass grafting (CABG) is associated with higher incidence of mediastinitis and mortality, and whether shorter intervals between median sternotomy and tracheotomy are associated with higher incidence of mediastinitis.
Patients (n = 6,057) undergoing CABG since March 1977 were reviewed. Patients requiring tracheostomy and those developing mediastinitis were identified. Mediastinitis diagnosis required positive culture of mediastinal tissue or fluid.
After CABG, 88 patients had tracheostomy performed (1.45%). Seven patients receiving tracheostomy after developing mediastinitis were excluded. Of the remaining 81 patients, 7 developed mediastinitis (8.6%) compared with 44 of 5,969 (0.7%) who did not require tracheostomy (p < 0.001). Mortality in tracheostomy patients was 24.7% (20 of 81) compared with 5.2% in patients not requiring tracheostomy (316 of 5,969; p < 0.001). Patients not developing mediastinitis had tracheostomy placement an average of 25 days after CABG compared with 18.7 days for those developing mediastinitis (p = 0.141).
Tracheostomy after CABG is associated with increased incidence of mediastinitis and mortality. In this review, the time interval between CABG and tracheostomy was not predictive of mediastinitis. A larger sample size would be required to be confident that there is no correlation.
我们研究了冠状动脉旁路移植术(CABG)后气管切开术是否与纵隔炎发生率和死亡率升高相关,以及正中胸骨切开术与气管切开术之间较短的间隔时间是否与纵隔炎发生率升高相关。
回顾了自1977年3月以来接受CABG的患者(n = 6,057)。确定了需要气管切开术的患者和发生纵隔炎的患者。纵隔炎的诊断需要纵隔组织或液体培养呈阳性。
CABG后,88例患者接受了气管切开术(1.45%)。7例在发生纵隔炎后接受气管切开术的患者被排除。在其余81例患者中,7例发生纵隔炎(8.6%),而5,969例不需要气管切开术的患者中有44例(0.7%)发生纵隔炎(p < 0.001)。气管切开术患者的死亡率为24.7%(81例中的20例),而不需要气管切开术的患者死亡率为5.2%(5,969例中的316例;p < 0.001)。未发生纵隔炎的患者在CABG后平均25天进行气管切开术,而发生纵隔炎的患者为18.7天(p = 0.141)。
CABG后气管切开术与纵隔炎发生率和死亡率增加相关。在本综述中,CABG与气管切开术之间的时间间隔不能预测纵隔炎。需要更大的样本量才能确定两者之间不存在相关性。