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Aprotinin: is it prothrombotic?

作者信息

Poullis M, Landis R C, Taylor K M

机构信息

National Heart and Lung Institute, Imperial College School of Medicine at Hammersmith, London, UK.

出版信息

Perfusion. 2001 Sep;16(5):401-9. doi: 10.1177/026765910101600510.

DOI:10.1177/026765910101600510
PMID:11565895
Abstract

Controversy continues as to whether aprotinin (Trasylol) is prothrombotic. The recent discovery of the thrombin receptor family, known as the protease-activated receptor family (PAR) has been essential in aiding our understanding of the mechanism of action of aprotinin. Our results show that aprotinin has no effect on platelet aggregation induced by adrenaline, adenosine diphosphate, phorbol-12-myristate-13-acetate, collagen or PAR 1 agonist peptide. However, aprotinin inhibits thrombin-induced platelet activation as assessed by macroaggregation, microaggregation and platelet membrane calcium flux. Aprotinin inhibits proteolytic activation of platelets, but platelets can still be activated by non-proteolytic mechanisms.

摘要

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