使用电子显微镜图像作为分子置换的模型。
Using electron-microscopy images as a model for molecular replacement.
作者信息
Dodson E J
机构信息
York Structural Biology Laboratory, Chemistry Department, University of York, York YO10 5DD, England.
出版信息
Acta Crystallogr D Biol Crystallogr. 2001 Oct;57(Pt 10):1405-9. doi: 10.1107/s0907444901013415. Epub 2001 Sep 21.
PMID:11567152
Abstract
This review addresses the technical problems encountered while using models based on electron microscopy to generate initial phases for crystallographic studies. The test cases used were the gp6 portal protein with 13-fold rotational symmetry and the human hepatitis virus HepB, a viral assembly with T = 4 icosohedral symmetry.
摘要
本综述探讨了在使用基于电子显微镜的模型为晶体学研究生成初始相位时遇到的技术问题。所使用的测试案例是具有13重旋转对称性的gp6门户蛋白和人类乙型肝炎病毒HepB，后者是一种具有T = 4二十面体对称性的病毒组装体。
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