Kessaris N, Pringle N, Richardson W D
Wolfson Institute for Biomedical Research and Department of Biology, University College London, Gower Street, WC1E 6AE, London, United Kingdom.
Neuron. 2001 Sep 13;31(5):677-80. doi: 10.1016/s0896-6273(01)00430-5.
In the developing spinal cord, neuroepithelial precursors at different positions along the dorsal-ventral axis generate distinct neuronal and glial subtypes. For example, one group of ventral precursors generates neurons followed by oligodendrocytes. A spate of recent articles, including several in this issue of Neuron, are devoted to the mechanisms governing neuronal and glial subtype specification in the ventral cord. We review these studies and discuss the nature of the ventral neuron-oligodendrocyte switch.
在发育中的脊髓中，沿背腹轴不同位置的神经上皮前体细胞会产生不同的神经元和胶质细胞亚型。例如，一组腹侧前体细胞先产生神经元，随后产生少突胶质细胞。最近有一系列文章，包括本期《神经元》杂志上的几篇文章，都致力于研究脊髓腹侧神经元和胶质细胞亚型特化的调控机制。我们综述了这些研究，并讨论了腹侧神经元-少突胶质细胞转换的本质。
