Nurkka A, Ahman H, Yaich M, Eskola J, Käyhty H
National Public Health Institute, Mannerheimintie 166, FIN-00300, Helsinki, Finland.
Vaccine. 2001 Oct 12;20(1-2):194-201. doi: 10.1016/s0264-410x(01)00250-x.
We studied the immunogenicity of two octavalent pneumococcal (Pnc) conjugate vaccines; Pnc polysaccharides (PS) of serotypes 3, 4, 6B, 9V, 14, 18C, 19F, and 23F were conjugated to diphtheria or tetanus toxoid (PncD and PncT, respectively). Fifty healthy Finnish infants were vaccinated at the ages of 2, 4, 6, and 15 months with either PncD or PncT. Serum IgG antibodies to the vaccine serotypes were analysed by enzyme-linked immunosorbent assay (EIA). All eight PSs induced a significant antibody response both after the primary series and after the booster. Response to PncD was higher for PSs 3, 9V, 14 and 18C and to PncT for serotype 4. Salivary IgA and IgG anti-Pnc antibodies were measured for serotypes 4, 6B, 9V, 14, 18C, and 19F. Mucosal antibodies were found rarely after the primary series but in a greater proportion after the booster. In conclusion, both vaccines were immunogenic.
我们研究了两种八价肺炎球菌（Pnc）结合疫苗的免疫原性；3、4、6B、9V、14、18C、19F和23F血清型的Pnc多糖（PS）分别与白喉类毒素或破伤风类毒素结合（分别为PncD和PncT）。五十名健康的芬兰婴儿在2、4、6和15月龄时接种了PncD或PncT。通过酶联免疫吸附测定（EIA）分析针对疫苗血清型的血清IgG抗体。所有八种PS在初次免疫系列后和加强免疫后均诱导了显著的抗体反应。对于3、9V、14和18C血清型，对PncD的反应更高，对于4血清型，对PncT的反应更高。检测了4、6B、9V、14、18C和,19F血清型的唾液IgA和IgG抗Pnc抗体。初次免疫系列后很少发现黏膜抗体，但加强免疫后比例更高。总之，两种疫苗均具有免疫原性。
