Ide T, Kushiro M, Takahashi Y
Laboratory of Nutrition Biochemistry, National Food Research Institute, 2-1-12 Kannondai, Tsukuba Science City, 305-8642, Ibaraki, Japan.
Comp Biochem Physiol B Biochem Mol Biol. 2001 Oct;130(3):401-9. doi: 10.1016/s1096-4959(01)00462-6.
Effects of dietary fats differing in fatty acid composition on insulin-stimulated glucose metabolism in adipocytes isolated from rat white adipose tissue were compared. Rats were fed experimental diets containing various fats differing in fatty acid composition for 7 days. In the first experiment, rats were fed palm oil mainly consisting of palmitic (45.3%) and oleic acids (39.1%) or safflower oil rich in linoleic acid (71.6%). In the second trial, rats were fed palm oil, or a fat mixture rich in linoleic acid or mold oil rich in gamma-linolenic acid. Contents of fatty acids except for linoleic and gamma-linolenic acid were comparable between the fat mixture and mold oil. The former was devoid of gamma-linolenic acid and contained 42.0% linoleic acid, while the latter contained 25.9% gamma-linolenic and 15.7% linoleic acids. In the first experiment, the insulin-dependent increase in glucose oxidation and incorporation into lipids was higher in rats fed safflower oil compared to those fed palm oil. In the second experiment, the insulin-dependent increase in glucose oxidation and incorporation into lipids was higher in rats fed the fat mixture and mold oil than in those fed palm oil. However, the extent of the increase in these parameters was much greater in rats fed mold oil than in those fed the fat mixture. Therefore, dietary gamma-linolenic acid compared to linoleic acid increases glucose metabolism in response to insulin stimuli in isolated rat adipocytes.
比较了脂肪酸组成不同的膳食脂肪对从大鼠白色脂肪组织分离的脂肪细胞中胰岛素刺激的葡萄糖代谢的影响。给大鼠喂食含有脂肪酸组成不同的各种脂肪的实验性饮食7天。在第一个实验中，给大鼠喂食主要由棕榈酸（45.3%）和油酸（39.1%）组成的棕榈油或富含亚油酸（71.6%）的红花油。在第二个试验中，给大鼠喂食棕榈油、富含亚油酸的脂肪混合物或富含γ-亚麻酸的霉菌油。脂肪混合物和霉菌油中亚油酸和γ-亚麻酸以外的脂肪酸含量相当。前者不含γ-亚麻酸，含有42.0%的亚油酸，而后者含有25.9%的γ-亚麻酸和15.7%的亚油酸。在第一个实验中，与喂食棕榈油的大鼠相比，喂食红花油的大鼠中胰岛素依赖性葡萄糖氧化增加和脂质掺入增加更高。在第二个实验中，喂食脂肪混合物和霉菌油的大鼠中胰岛素依赖性葡萄糖氧化增加和脂质掺入增加高于喂食棕榈油的大鼠。然而，喂食霉菌油的大鼠中这些参数的增加程度比喂食脂肪混合物的大鼠大得多。因此，与亚油酸相比，膳食γ-亚麻酸可增加分离的大鼠脂肪细胞中胰岛素刺激下的葡萄糖代谢。
