Guzmán-Flores Juan Manuel, Pérez-Vázquez Victoriano, Martínez-Esquivias Fernando, Isiordia-Espinoza Mario Alberto, Viveros-Paredes Juan Manuel
Instituto de Investigación en Biociencias, Centro Universitario de los Altos, Universidad de Guadalajara, Tepatitlán de Morelos C.P. 47620, Jalisco, Mexico.
Department of Medical Sciences, University of Guanajuato, Campus León, León C.P. 37220, Guanajuato, Mexico.
Curr Issues Mol Biol. 2023 Sep 1;45(9):7228-7241. doi: 10.3390/cimb45090457.
The incidence of type 2 diabetes (T2D) is rising, and finding new treatments is important. is a plant suggested as a potential treatment for T2D, but how it works needs to be clarified. This study explored the pharmacological mechanism of in treating T2D. We identified the active compounds in and their targets. From there, we examined the genes associated with T2D and found overlapping genes. We conducted an enrichment analysis and created a protein-protein and target-compound interactions network. We confirmed the binding activities of the hub proteins and compounds with molecular docking. We identified thirteen active compounds from , which have 150 therapeutic targets in T2D. The enrichment analysis showed that these proteins are involved in the hormone, lipid, and stress responses. They bind transcription factors and metals and participate in the insulin, PI3K/Akt, HIF-1, and FoxO signaling pathways. We found four hub proteins (EGFR, ESR1, HSP90AA1, and SRC) that bind to the thirteen bioactive compounds. This was verified using molecular docking. Our findings suggest that 's antidiabetic action is carried out through the insulin signaling pathway, with the participation of HIF-1 and FoxO.
2型糖尿病（T2D）的发病率正在上升，寻找新的治疗方法很重要。[某种植物名称]被认为是一种潜在的T2D治疗方法，但其作用机制尚需阐明。本研究探讨了[该植物名称]治疗T2D的药理机制。我们鉴定了[该植物名称]中的活性化合物及其靶点。在此基础上，我们研究了与T2D相关的基因并发现了重叠基因。我们进行了富集分析并构建了蛋白质-蛋白质和靶点-化合物相互作用网络。我们通过分子对接证实了枢纽蛋白和化合物的结合活性。我们从[该植物名称]中鉴定出13种活性化合物，它们在T2D中有150个治疗靶点。富集分析表明，这些蛋白质参与激素、脂质和应激反应。它们结合转录因子和金属，并参与胰岛素、PI3K/Akt、HIF-1和FoxO信号通路。我们发现有4种枢纽蛋白（EGFR、ESR1、HSP90AA1和SRC）与这13种生物活性化合物结合。这通过分子对接得到了验证。我们的研究结果表明，[该植物名称]的抗糖尿病作用是通过胰岛素信号通路实现的，HIF-1和FoxO也参与其中。
