Lindén C, Alm A
Department of Clinical Science, Ophthalmology, Umeå University, SE-901 85 Umeå, Sweden.
Br J Ophthalmol. 2001 Oct;85(10):1163-6. doi: 10.1136/bjo.85.10.1163.
To compare the effect on intraocular pressure (IOP) of latanoprost applied once daily with four times daily and to study if the difference persisted when treatment changed to once daily.
IOP was followed in 28 healthy volunteers in a double masked randomised 52 day study. Latanoprost 50 microg/ml was administered once daily in one eye and four times daily in the other during 2 weeks. Subsequently both eyes received one daily drop for 2 weeks. After another 3 weeks without treatment, a single drop was instilled in each eye.
The IOP reduction on days 2 and 3 was greater in the eyes treated with four daily doses (p<0.01). During the following period there were no statistically significant differences between the eyes. After 3 weeks without treatment the IOP was lower than pretreatment (p<0.001). A single dose of latanoprost on day 50 resulted in a similar decrease in IOP in both eyes. Transient photophobia, mild flare, and/or a few cells occurred in 15 subjects. Two subjects were withdrawn because of photophobia and/or signs of anterior uveitis.
Latanoprost four times daily caused an IOP reducing effect which was similar to once daily dosing, except for the first 2 days of treatment when it was more effective. Transient photophobia, cells, and flare were common during the four dose regimen, but resolved spontaneously without cessation of treatment.
比较每天一次使用拉坦前列素与每天四次使用拉坦前列素对眼压（IOP）的影响，并研究当治疗改为每天一次时这种差异是否持续存在。
在一项双盲随机52天研究中，对28名健康志愿者的眼压进行跟踪。在2周内，一只眼睛每天滴注一次50微克/毫升的拉坦前列素，另一只眼睛每天滴注四次。随后，两只眼睛均每天滴注一次，持续2周。在又3周不治疗后，每只眼睛滴入一滴。
在第2天和第3天，每天接受四次给药的眼睛眼压降低幅度更大（p<0.01）。在接下来的时期，两只眼睛之间没有统计学上的显著差异。在3周不治疗后，眼压低于治疗前（p<0.001）。在第50天，单剂量的拉坦前列素使两只眼睛的眼压下降幅度相似。15名受试者出现短暂畏光、轻度房水闪辉和/或少量细胞。两名受试者因畏光和/或前葡萄膜炎迹象而退出。
拉坦前列素每天四次给药除在治疗的前两天更有效外，其降低眼压的效果与每天一次给药相似。在四剂量方案期间，短暂畏光、细胞和房水闪辉很常见，但无需停止治疗即可自行缓解。
