Ball P A
Clinical Pharmacy, University of Otago, Dunedin, New Zealand.
Curr Opin Clin Nutr Metab Care. 2001 Sep;4(5):345-9. doi: 10.1097/00075197-200109000-00003.
Increased use of intravenous in-line filtration for all-in-one admixtures has been one of several recent stimuli to developing methods for assessing the stability of parenteral nutrition regimens. Admixture formulations previously deemed to be 'stable' have caused filter blockage and this requires urgent reconsideration of the definitions of physical emulsion stability. The new technique of acoustic attenuation spectroscopy has been evaluated as another means of assessing physical stability of emulsions, and some of the newer techniques have been further applied to provide additional insight into the effects of light and oxygen. There has also been additional work on trace element contamination and changes in trace element concentrations on storage. Overall this review period has been one of evolution rather than revolution.
对一体化混合液增加使用静脉内在线过滤，是近期推动肠外营养方案稳定性评估方法发展的诸多因素之一。以前被认为“稳定”的混合液配方导致了过滤器堵塞，这需要紧急重新考虑物理乳液稳定性的定义。声衰减光谱新技术已被评估为评估乳液物理稳定性的另一种手段，并且一些更新的技术已被进一步应用，以更深入了解光和氧的影响。关于微量元素污染以及储存时微量元素浓度变化也有更多研究。总体而言，这个综述期是一个演变而非变革的时期。
