Grant G, Arvidsson J
Brain Res. 1975 Sep 23;95(2-3):265-79. doi: 10.1016/0006-8993(75)90106-7.
In 16 kittens either the frontal or the inferior alveolar nerve was transected and in 17 adult rats either the supraorbital, the infraorbital or the mental nerve was divided. The postoperative survival periods were kept at 3-28 days for the kittens and 15-26 days for the rats. Sections from the caudal brain stem and the upper part of the cervical cord were impregnated according to the Fink-Heimer method, procedure II. In the kittens degeneration was found after the 8th postoperative day ipsilaterally in both the spinal and main sensory trigeminal nuclei and the spinal trigeminal tract. In the rats degeneration was found in all cases in the same ipsilateral structures as in the kittens. The amount of degeneration was relatively great in the rats, whereas it was very modest in the kittens. A somatotopical pattern was found for the degeneration both within the spinal and the main sensory nuclei. It was in agreement with what has been found in earlier studies, where other techniques have been used. By a comparison with the results of a previous study on the trigeminal nerve in the rat, where partial lesions of the ganglia had been made, it was found that the degeneration in the present study did not cover the whole area receiving primary trigeminal afferents. Possible explanations for this are discussed.
在16只小猫中，切断其面神经或下牙槽神经；在17只成年大鼠中，切断其眶上神经、眶下神经或颏神经。小猫的术后存活期为3 - 28天，大鼠为15 - 26天。按照芬克 - 海默法步骤II，对延髓尾端和颈髓上部进行切片浸染。在小猫中，术后第8天起，在同侧的脊髓三叉神经主核、感觉三叉神经核以及脊髓三叉神经束均发现了变性。在大鼠中，所有病例在同侧与小猫相同的结构中均发现了变性。大鼠中的变性量相对较大，而小猫中的变性量则非常小。在脊髓和主感觉核内均发现了变性的躯体定位模式。这与早期使用其他技术的研究结果一致。通过与先前一项关于大鼠三叉神经节部分损伤的研究结果进行比较，发现本研究中的变性并未覆盖接受三叉神经初级传入纤维的整个区域。文中讨论了对此现象的可能解释。
