Schunk K, Reiter S, Kern A, Orth T, Wanitschke R
Klinik und Poliklinik für Radiologie, Klinikum der Johannes Gutenberg-Universität, Mainz.
Rofo. 2001 Aug;173(8):731-8. doi: 10.1055/s-2001-16400.
To compare hydro-MRI with colonoscopy and biopsy specimen regarding the assessment of inflammatory activity and the differentiation of inflammatory bowel diseases.
After an oral bowel opacification using 1000 ml of a 2.5% mannitol solution and a rectal bowel opacification using 250-500 ml of a 0.9% saline solution, axial and coronal breath-hold sequences +/- Gd-DTPA (HASTE-["half-Fourier acquisition single-shot turbo spin echo"] and dynamic FLASH-["fast low angle shot"]) were acquired in 27 patients with inflammatory bowel disease. The enhancement of the bowel wall as well as morphological MRI findings were correlated with colonoscopy and biopsy specimens. By means of the MRI findings, Crohn's disease (CD) and ulcerative colitis (UC) should be differentiated.
In CD, a significant correlation between the contrast enhancement of the inflamed bowel wall (delta SI) and the endoscopic/histopathologic indices could be established (r = 0.52; p = 0.02 and r = 0.72; p = 0.001). In UC, no correlations between delta SI and the endoscopic/histopathologic indices could be found. The correct diagnosis of CD and UC by MRI findings was possible in 22/27 patients (81%).
Hydro-MRI with dynamic studies is suitable for the assessment of disease activity in CD, but unreliable in UC. Hydro-MRI provides useful information for the differentiation of CD and UC.
比较水磁共振成像（hydro - MRI）与结肠镜检查及活检标本在评估炎症活动度和鉴别炎性肠病方面的差异。
对27例炎性肠病患者，口服1000 ml 2.5%甘露醇溶液进行肠道造影，直肠注入250 - 500 ml 0.9%生理盐水进行肠道造影后，采用轴位和冠状位屏气序列±钆喷酸葡胺（HASTE - ["半傅里叶采集单次激发快速自旋回波"]和动态FLASH - ["快速低角度激发"]）进行成像。肠壁强化情况以及MRI形态学表现与结肠镜检查及活检标本进行相关性分析。通过MRI表现对克罗恩病（CD）和溃疡性结肠炎（UC）进行鉴别。
在CD中，可建立炎症肠壁对比增强（δSI）与内镜/组织病理学指标之间的显著相关性（r = 0.52；p = 0.02和r = 0.72；p = 0.001）。在UC中，未发现δSI与内镜/组织病理学指标之间存在相关性。通过MRI表现正确诊断CD和UC的患者有22/27例（81%）。
动态水磁共振成像适用于评估CD的疾病活动度，但在UC中不可靠。水磁共振成像为CD和UC的鉴别提供了有用信息。
