小猫早期单眼剥夺后，当双眼睁开时，视力的最初恢复更快。
Initial recovery of vision after early monocular deprivation in kittens is faster when both eyes are open.
作者信息
Mitchell D E, Gingras G, Kind P C
机构信息
Department of Psychology, Dalhousie University, Halifax, NS, Canada.
出版信息
Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11662-7. doi: 10.1073/pnas.201392698.
A comparison was made of the speed of visual recovery in the deprived eye of kittens after a 6-day period of monocular deprivation imposed at 5-9 weeks of age in two postdeprivation conditions. In one condition, binocular recovery (BR), both eyes were open, whereas in the other condition, reverse lid-suture (RLS), the formerly nondeprived eye was closed to force the animal to use the originally deprived eye. In littermate pairs, BR kittens began to recover form vision 12 to 30 h before those subjected to RLS. The vision of the deprived eye of the BR animals remained superior to that of their RLS littermates for 4-8 days. Although this finding is difficult to reconcile with competitive mechanisms of synaptic plasticity, it supports a prediction of an alternative model of synaptic plasticity [Bienenstock, E. L., Cooper, L. N. & Munro, P. W. (1982) J. Neurosci. 2, 32-48] for slower initial recovery with RLS because of the time required to reset the modification threshold.
对两组在5至9周龄时经历6天单眼剥夺的小猫在剥夺后的两种条件下，其被剥夺眼的视觉恢复速度进行了比较。在一种条件下，即双眼恢复（BR），双眼均睁开；而在另一种条件下，即反向眼睑缝合（RLS），先前未被剥夺的眼睛被闭合，以迫使动物使用最初被剥夺的眼睛。在同窝配对中，BR组小猫比RLS组小猫提前12至30小时开始恢复视力。BR组动物被剥夺眼的视力在4至8天内一直优于其RLS组的同窝伙伴。尽管这一发现难以与突触可塑性的竞争机制相协调，但它支持了一种突触可塑性替代模型[比恩斯托克，E.L.，库珀，L.N.和芒罗，P.W.（1982年）《神经科学杂志》2，32 - 48]的预测，即由于重置修饰阈值所需的时间，RLS组的初始恢复较慢。
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