Pepperkok R, Simpson J C, Wiemann S
Department of Cell Biology and Biophysics, European Molecular Biology Laboratory Heidelberg, Meyerhofstrasse, 69117 Heidelberg, Germany.
Genome Biol. 2001;2(9):REVIEWS1024. doi: 10.1186/gb-2001-2-9-reviews1024. Epub 2001 Aug 29.
Taking each coding sequence from the human genome in turn and identifying the subcellular localization of the corresponding protein would be a significant contribution to understanding the function of each of these genes and to deciphering functional networks. This article highlights current approaches aimed at achieving this goal.
依次获取人类基因组中的每个编码序列,并确定相应蛋白质的亚细胞定位,这将对理解这些基因中每一个的功能以及破译功能网络做出重大贡献。本文重点介绍了旨在实现这一目标的当前方法。