鞘内注射S(+)-氯胺酮对已产生吗啡耐受性患者的长期抗伤害感受作用。
The long-term antinociceptive effect of intrathecal S(+)-ketamine in a patient with established morphine tolerance.
作者信息
Sator-Katzenschlager S, Deusch E, Maier P, Spacek A, Kress H G
机构信息
Department of Anesthesiology and Intensive Care B, University of Vienna, Vienna, Austria.
出版信息
Anesth Analg. 2001 Oct;93(4):1032-4, table of contents. doi: 10.1097/00000539-200110000-00047.
Our report describes for the first time the continuous long-term intrathecal application of S(+)-ketamine in a patient with chronic pain and morphine tolerance. Intrathecally applied S(+)-ketamine led to a significant pain reduction and consecutively reduced the doses of intrathecal morphine required for pain relief even several weeks after the cessation of the 24-day period of intrathecal S(+)-ketamine administration.
我们的报告首次描述了S(+)-氯胺酮在一名患有慢性疼痛且对吗啡耐受的患者中进行持续长期鞘内给药的情况。鞘内注射S(+)-氯胺酮可显著减轻疼痛，甚至在鞘内注射S(+)-氯胺酮24天的给药期结束数周后，仍能持续减少缓解疼痛所需的鞘内吗啡剂量。
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