[硫代磷酰胺对中国仓鼠细胞培养物细胞周期各阶段姐妹染色单体交换的诱导作用]
[Thiophosphamide induction of sister chromatid exchanges at various phases in the cell cycle of a Chinese hamster cell culture].
作者信息
Chebotarev A N, Selezneva T G
出版信息
Genetika. 1979;15(10):1841-6.
Influence of three concentrations of thiophosphamide (thioTEPA) on the formation of sister chromatid exchanges (SCE) has been studied at different phases during 2 cell cycles in cultured Chinese hamster cells. It is shown that the frequency of SCE does not differ from the control level under the effect of the mutagen on cells in the G2 phase of the first cell cycle from the moment of harvesting. Thiophosphamide induces the same number of SCE at S, G1 stages of the first cell cycle and G2 of the second one till the moment of harvesting. The number of SCE correlates in a direct proportion with a concentration of thiophosphamide. A scheme of forming SCE is proposed.
研究了三种浓度的硫代磷酰胺（噻替派）对培养的中国仓鼠细胞在两个细胞周期不同阶段姐妹染色单体交换（SCE）形成的影响。结果表明，从收获时刻起，在第一个细胞周期的G2期，诱变剂作用下的SCE频率与对照水平无差异。直到收获时刻，硫代磷酰胺在第一个细胞周期的S期、G1期以及第二个细胞周期的G2期诱导产生的SCE数量相同。SCE的数量与硫代磷酰胺的浓度成正比。提出了SCE形成的示意图。
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