Stukalov S V, Chebotarev A N
Biull Eksp Biol Med. 1983 Apr;95(4):74-5.
The effects of thiophosphamide on rabbit lymphocytes were studied and compared in vivo and in vitro. In the course of in vitro action the dose was calculated by multiplying the thiophosphamide concentration by the time of in vitro treatment. In vivo the dose was calculated as integral of concentration variation function of thiophosphamide from the time of injection till the time of blood collection. It was demonstrated that as the dose was raised, the rate of sister chromatid exchanges increased linearly in vivo and in vitro. The coefficients of linear regressions were found to coincide. The data point to equal efficacy of thiophosphamide in vivo and in vitro.
研究并比较了硫代磷酰胺对家兔淋巴细胞的体内和体外作用。在体外作用过程中，剂量通过硫代磷酰胺浓度乘以体外处理时间来计算。在体内，剂量按注射后至采血时硫代磷酰胺浓度变化函数的积分来计算。结果表明，随着剂量增加，体内和体外姐妹染色单体交换率均呈线性增加。发现线性回归系数相符。这些数据表明硫代磷酰胺在体内和体外具有同等效力。
