Inoue S, Kawaguchi M, Sakamoto T, Iwata T, Kawaraguchi Y, Furuya H, Sakaki T
Department of Anaesthesiology, Nara Medical University, Kashihara, Japan.
Br J Anaesth. 2001 May;86(5):663-8. doi: 10.1093/bja/86.5.663.
We investigated the effects of i.v. amrinone on intraoperative changes of core temperature during deliberate mild hypothermia for neurosurgery. The patients in a control group (n=10) did not receive amrinone and patients in the amrinone group (n=10) received amrinone 5 microg kg(-1) min(-1) after a loading dose of 1.0 mg kg(-1). Anaesthesia was maintained with nitrous oxide in oxygen, propofol and fentanyl. After the induction of anaesthesia, patients were cooled and tympanic membrane temperature was maintained at 34.5 degrees C. After completion of the main surgical procedures, patients were rewarmed in the operating room. Tympanic membrane temperatures between 30 and 90 min after cooling were significantly lower in the amrinone group than in the control group. During cooling, the times taken to cool to 35 degrees C and to the lowest temperature were significantly shorter in the amrinone group than in the control group. These results suggest that i.v. amrinone can accelerate the cooling rate of core temperature during deliberate mild hypothermia for neurosurgical procedures.
我们研究了静脉注射氨力农对神经外科手术中实施轻度低温时核心体温术中变化的影响。对照组（n = 10）患者未接受氨力农，氨力农组（n = 10）患者在给予1.0 mg/kg负荷剂量后，接受5 μg·kg⁻¹·min⁻¹的氨力农。麻醉维持采用氧化亚氮、氧气、丙泊酚和芬太尼。麻醉诱导后，患者进行降温，鼓膜温度维持在34.5℃。主要手术步骤完成后，患者在手术室进行复温。降温后30至90分钟，氨力农组的鼓膜温度显著低于对照组。在降温过程中，氨力农组降至35℃和最低温度所需的时间显著短于对照组。这些结果表明，静脉注射氨力农可加快神经外科手术中实施轻度低温时核心体温的降温速率。
