Rosenberg D R, Amponsah A, Sullivan A, MacMillan S, Moore G J
Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, USA.
J Child Neurol. 2001 Sep;16(9):636-41. doi: 10.1177/088307380101600902.
The thalamus has been implicated in the pathophysiology of obsessive-compulsive disorder. Using a multislice spectroscopic imaging sequence, we reported reductions in right and left medial thalamic N-acetylaspartate/cytosolic choline + creatine/phosphocreatine and N-acetylaspartate/cytosolic choline levels in 11 pediatric patients with obsessive-compulsive disorder, 8 to 15 years, versus 11 case-matched healthy controls. These changes may reflect a change in N-acetylaspartate, cytosolic choline, or creatine concentrations. Therefore, using a validated phantom replacement methodology, we obtained absolute measures (mmol/L) of N-acetylaspartate, a putative marker of neuronal viability, cytosolic choline, and creatine in these subjects. A significant increase in cytosolic choline was observed in right and left medial but not lateral thalami in patients with obsessive-compulsive disorder versus controls. N-acetylaspartate and creatine did not differ significantly between case-control pairs in the medial or lateral thalamus. These findings provide new evidence of cytosolic choline abnormalities in the thalamus in pediatric obsessive-compulsive disorder.
丘脑已被认为与强迫症的病理生理学有关。我们使用多层磁共振波谱成像序列，报告了11名8至15岁的小儿强迫症患者与11名年龄匹配的健康对照相比，左右内侧丘脑的N-乙酰天门冬氨酸/胞质胆碱+肌酸/磷酸肌酸以及N-乙酰天门冬氨酸/胞质胆碱水平降低。这些变化可能反映了N-乙酰天门冬氨酸、胞质胆碱或肌酸浓度的改变。因此，我们采用经过验证的体模替代方法，获得了这些受试者中N-乙酰天门冬氨酸（一种推测的神经元活力标志物）、胞质胆碱和肌酸的绝对测量值（mmol/L）。与对照组相比，强迫症患者左右内侧丘脑而非外侧丘脑中的胞质胆碱显著增加。内侧或外侧丘脑中病例对照对之间的N-乙酰天门冬氨酸和肌酸没有显著差异。这些发现为小儿强迫症患者丘脑中胞质胆碱异常提供了新证据。
