Sohn J H, Kim L S, Chae S W, Shin H S
Department of Pathology, Hangang Sacred Heart Hospital, College of Medicine, Hallym University, Seoul, Korea.
Acta Cytol. 2001 Sep-Oct;45(5):723-9. doi: 10.1159/000328294.
To report the cytologic findings of mucocelelike tumor and mucinous carcinoma.
All mucinous neoplasms diagnosed by fine needle aspiration and confirmed by histologic examination were reviewed to detect the cytologic findings helpful for the differentiation. The cytologic findings were correlated with the histologic findings.
Cytologically, mucinous carcinomas were highly cellular and showed many single epithelial cells and variably formed epithelial cell clusters in abundant extracellular mucin. Malignant cells exhibited round, atypical nuclei; granular chromatin; and small nucleoli. Mucocele like tumor showed low cellularity with scanty, monolayered, small sheets of epithelial cells and abundant, extracellular mucin. Myoepithelial cells were present within the epithelial cell sheets. Tumor cells were usually small, with uniform, round nuclei; fine chromatin; and absence of nucleoli.
Cytologic findings of mucocelelike tumor and mucinous carcinoma were different in cellularity, shape of cell clusters and nuclear features, although mucocelelike tumors having a carcinoma component were similar to mucinous carcinoma. Awareness of the cytologic findings of breast mucinous neoplasms is important to make a specific diagnosis.
报告黏液囊肿样肿瘤和黏液腺癌的细胞学表现。
回顾所有经细针穿刺诊断并经组织学检查证实的黏液性肿瘤，以检测有助于鉴别诊断的细胞学表现。将细胞学表现与组织学表现进行关联。
在细胞学上，黏液腺癌细胞丰富，可见许多单个上皮细胞以及在大量细胞外黏液中形成的大小不一的上皮细胞簇。恶性细胞表现为圆形、非典型核；颗粒状染色质；以及小核仁。黏液囊肿样肿瘤细胞数量少，有少量单层小片状上皮细胞和丰富的细胞外黏液。上皮细胞片内可见肌上皮细胞。肿瘤细胞通常较小，核均匀、圆形；染色质细腻；无核仁。
黏液囊肿样肿瘤和黏液腺癌的细胞学表现在细胞数量、细胞簇形状和核特征方面有所不同，尽管具有癌成分的黏液囊肿样肿瘤与黏液腺癌相似。了解乳腺黏液性肿瘤的细胞学表现对于做出明确诊断很重要。
