Bhatia Arati, Malhotra Geetu, Grover Punita, Singh Navjeevan
Department of Pathology, University College of Medical Sciences and GTB Hospital, Delhi, India.
J Cytol. 2011 Oct;28(4):196-9. doi: 10.4103/0970-9371.86347.
Secretions are seen in a range of breast cancer that includes invasive ductal carcinoma, mucinous carcinoma and secretory carcinoma. Evaluation of the quantity and location of secretions and the contours of the cell clusters complement cell morphology could improve diagnostic cytopathological criteria.
To identify the range of breast carcinomas with secretions on fine-needle aspiration.
A retrospective study of 160 patients with breast carcinoma was carried out. The tumors were typed by evaluating the quantity and location of secretions, cellularity and nuclear grade.
Secretions were seen in 16 of 160 breast carcinomas. Eleven were invasive ductal carcinoma (IDC), three were mucinous and two were secretory carcinomas. In IDC, minimal intracytoplasmic secretions were seen in 10, nuclear grades of 2 and 3 in 9, cell clusters with irregular margins in 6, and necrosis in 4. All mucinous and secretory carcinomas were nuclear grade 1. Extensive extracellular secretions and cell clusters with rounded contours were seen in mucinous carcinomas. In secretory carcinomas, the secretions were predominantly intracellular; stringy vasculature was a unique feature.
Secretions in breast cancer are seen in a range of lesions that include IDC, mucinous, and secretory carcinomas. The quantity and location of secretions in breast cancer offer clues to differentiating these.
在一系列乳腺癌中可见分泌物，包括浸润性导管癌、黏液癌和分泌性癌。评估分泌物的数量和位置以及细胞簇的轮廓并结合细胞形态学，可改善诊断性细胞病理学标准。
确定细针穿刺时出现分泌物的乳腺癌范围。
对160例乳腺癌患者进行回顾性研究。通过评估分泌物的数量和位置、细胞密度和核分级对肿瘤进行分型。
160例乳腺癌中有16例可见分泌物。11例为浸润性导管癌（IDC），3例为黏液癌，2例为分泌性癌。在IDC中，10例可见少量胞质内分泌物，9例核分级为2级和3级，6例细胞簇边缘不规则，4例有坏死。所有黏液癌和分泌性癌核分级均为1级。黏液癌可见大量细胞外分泌物和轮廓圆形的细胞簇。在分泌性癌中，分泌物主要为细胞内的；条索状脉管系统是其独特特征。
乳腺癌中的分泌物可见于一系列病变，包括IDC、黏液癌和分泌性癌。乳腺癌中分泌物的数量和位置为鉴别这些病变提供了线索。
