Cardoso S V, Moreti M M, Costa I M, Loyola A M
Department of Oral Pathology, School of Dentistry, Federal University of Uberlandia, Minas Gerais, Brazil.
Oral Dis. 2001 Jul;7(4):217-20.
To describe the main cytological findings associated with smears collected from oral lesions of paracoccidioidomycosis and to appraise the use of cytology as a diagnostic tool for the disease.
Cytological smears and biopsies were collected from 40 lesions with a clinical suspicion of paracoccidioidomycosis. Evaluation of the sensitivity, specificity, positive and negative predictive values, accuracy and the positive likeness ratio of the oral smear when compared with the histological diagnosis, was performed. The latter is considered the 'gold standard' for comparison.
The main morphological findings were the rounded-shaped, birefringent and multiple-budded fungi, Langhans' giant cells and epithelioid cells. The following associative measures were found: sensitivity, 67.9%; specificity, 91.7%; positive predictive value, 95.0%; negative predictive value, 55.0%; accuracy, 75.0%; and positive likeness ratio, 8.14.
The cytological findings of paracoccidioidomycosis are characteristic and cytology is accurate in the diagnosis of the disease. Positive patients should be treated. Negative patients should be submitted to biopsy to confirm or to dismiss the diagnosis of this mycosis.
描述与副球孢子菌病口腔病变涂片相关的主要细胞学发现，并评估细胞学作为该疾病诊断工具的应用。
从40例临床怀疑为副球孢子菌病的病变中采集细胞学涂片和活检样本。将口腔涂片与组织学诊断进行比较，评估其敏感性、特异性、阳性和阴性预测值、准确性以及阳性似然比。后者被视为比较的“金标准”。
主要形态学发现为圆形、双折光且多芽生的真菌、朗汉斯巨细胞和上皮样细胞。发现以下关联指标：敏感性为67.9%；特异性为91.7%；阳性预测值为95.0%；阴性预测值为55.0%；准确性为75.0%；阳性似然比为8.14。
副球孢子菌病的细胞学发现具有特征性，细胞学在该疾病的诊断中准确。阳性患者应接受治疗。阴性患者应进行活检以确诊或排除该真菌病的诊断。
