胰岛素样生长因子及胰岛素样生长因子结合蛋白：肿瘤生长诊断与监测的替代标志物？
IGFs and IGFBPs: surrogate markers for diagnosis and surveillance of tumour growth?
作者信息
Zumkeller W
机构信息
Department of Paediatrics, Martin-Luther-University Halle-Wittenberg, Ernst-Grube-Str. 40, 06097 Halle/Saale, Germany.
出版信息
Mol Pathol. 2001 Oct;54(5):285-8. doi: 10.1136/mp.54.5.285.
Abstract
Insulin-like growth factors (IGFs), IGF receptors, and IGF binding proteins (IGFBPs) constitute the IGF system. Comprehensive data indicate that these factors play a pivotal role in tumorigenesis. Epidemiological data indicate that cancer risk is associated with high serum IGF-I values. Because dysregulation of the IGF system is a frequent pattern in malignancy, IGFs/IGFBPs might represent novel tumour markers that could be useful both for diagnosis and surveillance.
摘要
胰岛素样生长因子（IGFs）、IGF受体和IGF结合蛋白（IGFBPs）构成了IGF系统。综合数据表明，这些因子在肿瘤发生过程中起关键作用。流行病学数据表明，癌症风险与血清IGF-I值升高有关。由于IGF系统失调在恶性肿瘤中是一种常见模式，IGFs/IGFBPs可能代表新型肿瘤标志物，对诊断和监测都可能有用。
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Sarcoma. 1998;2(2):69-76. doi: 10.1080/13577149878028.
2
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3
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Ann Surg Oncol. 2001 Jan-Feb;8(1):25-31. doi: 10.1007/s10434-001-0025-5.
4
Evaluation of plasma insulin-like growth factor binding protein-2 as a marker for adrenocortical tumors.评估血浆胰岛素样生长因子结合蛋白-2作为肾上腺皮质肿瘤标志物的作用。
Eur J Endocrinol. 2001 Jan;144(1):29-36. doi: 10.1530/eje.0.1440029.
5
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J Clin Endocrinol Metab. 2001 Feb;86(2):694-9. doi: 10.1210/jcem.86.2.7211.
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8
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