Schöndorf T H, Hey D
Dtsch Med Wochenschr. 1975 Oct 3;100(40):2014-8. doi: 10.1055/s-0028-1106493.
Low doses of heparin were administered subcutaneously to 103 patients starting the evening before major hip operations, while a further 95 were given calcium heparinate, starting the night after operation in conventional high doses. No anticoagulants were given to 27 patients who served as controls. In none of the patients given anticoagulants was there an increased incidence of postoperative wound complications. But the rate of thrombo-embolism was significantly reduced among those on conventional high doses of heparin. The rate of thromboembolism was also reduced among those on the lower dosage (compared with the control subjects), but this form of prophylaxis was not as effective for patients especially at risk.
103例患者在大髋关节手术前一晚开始皮下注射低剂量肝素,另外95例患者在术后当晚开始常规高剂量注射肝素钙。27例患者作为对照未给予抗凝剂。在给予抗凝剂的患者中,术后伤口并发症的发生率均未增加。但接受常规高剂量肝素治疗的患者血栓栓塞率显著降低。低剂量组患者的血栓栓塞率也有所降低(与对照组相比),但这种预防形式对高危患者效果不佳。