Schöndorf T H
Dtsch Med Wochenschr. 1978 Nov 24;103(47):1877-81. doi: 10.1055/s-0028-1129361.
Using the 125I-fibrinogen test, the antithrombotic effect of three different heparin schedules was examined in 113 patients untergoing elective hip surgery. Low-dose heparin (3 X 5000 IU/24 h) reduced the incidence of postoperative thrombosis from 60% in the control subjects (not receiving any heparin) to 33%. Combined low-dose heparin and acetylsalicyl-lysine, given intravenously, further reduced the incidence slightly to 27%. Increasing the heparin dosage postoperatively to 3 X 7500 IU/24 h effectively prevented the incidence of thrombosis by reducing it to 11% in these high-risk patients.
采用¹²⁵I-纤维蛋白原试验，在113例行择期髋关节手术的患者中研究了三种不同肝素给药方案的抗血栓形成作用。小剂量肝素（3×5000IU/24小时）使术后血栓形成的发生率从对照组（未接受任何肝素）的60%降至33%。静脉给予小剂量肝素与乙酰水杨酸赖氨酸联合用药，可使发生率进一步轻微降至27%。术后将肝素剂量增至3×7500IU/24小时，可有效预防血栓形成，使这些高危患者的发生率降至11%。
