Bahary N, Zon L I
Department of Adult Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
Science. 2001 Oct 19;294(5542):530-1. doi: 10.1126/science.1066282. Epub 2001 Sep 27.
Endothelial cells in blood vessels are known to be important during the later stages of organ development in the embryo. However, their involvement at the induction stage of organ formation has not been previously documented. As Bahary and Zon explain in their Perspective, new work demonstrates that endothelial cells secrete factors early in development that induce embryonic endoderm to become liver or pancreas (Matsumoto et al., Lammert et al.).
血管中的内皮细胞在胚胎器官发育的后期阶段起着重要作用，这是已知的。然而，它们在器官形成诱导阶段的参与此前尚未有文献记载。正如巴哈里和宗在他们的“观点”文章中所解释的，新的研究表明，内皮细胞在发育早期分泌因子，诱导胚胎内胚层发育成肝脏或胰腺（松本等人、拉默特等人）。
