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[吉兰-巴雷综合征相关空肠弯曲菌彭纳2型血清型:一例报告]

[Guillain-barré syndrome associated Campylobacter jejuni serotype Penner 2: a case report].

作者信息

Watanabe M, Kinoshita I, Hujimoto M, Nakane S, Motomura M, Nakamura T, Kusunoki S, Takahashi M, Saitoh K

机构信息

Department of Internal Medicine, Japanese Red Cross Nagasaki Atomic Bomb Hospital, 3-15 Mori-machi, Nagasaki 852-8511, Japan.

出版信息

No To Shinkei. 2001 Aug;53(8):759-62.

Abstract

We described a 15-year-old male who had Guillain-Barré syndrome(GBS). Nine days after watery diarrhea, the patient developed pain and weakness of foot muscles. On admission, the nerve conduction studies revealed peripheral neuropathy with axonal degeneration and demyelination. Campylobacter jejuni(C. jejuni) with serotype of Lior 4, Penner 2 was isolated from his stool culture. IgM anti-GM 1 antibody and other various anti-ganglioside antibodies were detected in his serum. After receiving plasma exchange and intravenous immunoglobulin therapy, he was able to walk without assistance. In general, C. jejuni with the serotype Penner 19 has been isolated from many GBS patients. In this patient, C. jejuni with the serotype of Penner 2 was isolated. The serotype is detected commonly in Miller Fisher syndrome.

摘要

我们描述了一名患有吉兰-巴雷综合征(GBS)的15岁男性。在出现水样腹泻九天后,患者出现足部肌肉疼痛和无力。入院时,神经传导研究显示为伴有轴突变性和脱髓鞘的周围神经病变。从他的粪便培养物中分离出了血清型为Lior 4、Penner 2的空肠弯曲菌(C. jejuni)。在他的血清中检测到IgM抗GM 1抗体和其他各种抗神经节苷脂抗体。在接受血浆置换和静脉注射免疫球蛋白治疗后,他能够独立行走。一般来说,许多GBS患者的粪便中分离出的是空肠弯曲菌血清型Penner 19。在该患者中,分离出的是空肠弯曲菌血清型Penner 2。这种血清型在米勒-费雪综合征中较为常见。

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