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1例空肠弯曲菌Penner 4型感染后与抗GM1b IgG抗体相关的轴索性吉兰-巴雷综合征病例

[A case of axonal form of Guillain-Barré syndrome associated with anti-GM1b IgG antibody following Penner 4 Campylobacter jejuni infection].

作者信息

Nagayama S, Kurohara K, Matsui M, Kuroda Y, Kusunoki S

机构信息

Department of Internal Medicine, Saga Medical School.

出版信息

Rinsho Shinkeigaku. 1997 Jun;37(6):506-8.

PMID:9366179
Abstract

A 41-year-old woman was admitted to the hospital because of diarrhea followed by progressive weakness of all extremities and dysphagia. On neurological examination, she showed facial diplegia, bulbar palsy, flaccid quadriplegia, and absence of all deep tendon reflexes in addition to Laségue's sign. The Campylobacter jejuni Penner type 4 was isolated from the culture of stool. The test of anti-GM1b antibody (IgG) was positive in the serum. The protein content was elevated in the cerebrospinal fluid without pleocytosis. The studies of motor nerve conduction velocity showed a pattern of the axonal neuropathy. This is a case of Guillain-Barré syndrome presenting with the axonal neuropathy possibly due to the immune response directed to GM1b which is triggered by the Campylobacter jejuni Penner type 4 infection.

摘要

一名41岁女性因腹泻入院,随后出现四肢进行性无力和吞咽困难。神经系统检查显示,除直腿抬高试验阳性外,她还存在双侧面瘫、延髓麻痹、弛缓性四肢瘫以及所有深腱反射消失。粪便培养分离出空肠弯曲菌彭纳4型。血清中抗GM1b抗体(IgG)检测呈阳性。脑脊液蛋白含量升高但无细胞增多。运动神经传导速度研究显示为轴索性神经病模式。这是一例吉兰-巴雷综合征,表现为轴索性神经病,可能是由于空肠弯曲菌彭纳4型感染引发针对GM1b的免疫反应所致。

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