Yamamoto Y, Nishiyama Y, Fukunaga K, Satoh K, Fujita J, Ohkawa M
Department of Radiology, Kagawa Medical University, Japan.
Ann Nucl Med. 2001 Aug;15(4):329-35. doi: 10.1007/BF02988239.
We evaluated the accumulation of 99mTc-MIBI in small cell lung cancer patients before chemotherapy and after unresponsive chemotherapy. The pre-chemotherapeutic group included 22 newly diagnosed patients. These patients underwent a 99mTc-MIBI SPECT study before starting chemotherapy. After chemotherapy, based on changes in tumor size, three different patterns of response (complete remission: CR, partial remission: PR and no change: NC) were defined. The post-chemotherapeutic group included 11 patients after chemotherapy who did not respond to chemotherapy. These patients underwent a 99mTc-MIBI SPECT study after completion of chemotherapy. SPECT images were acquired 15 min (early) and 2 hr (delayed) after injection of 99mTc-MIBI. With a region of interest technique, the early ratio, delayed ratio and retention index were calculated. Early and delayed ratios in pre-chemotherapeutic patients were significantly higher than those in post-chemotherapeutic patients. There were no significant differences between the pre-chemotherapeutic and post-chemotherapeutic patients in the retention index. In the pre-chemotherapeutic patients, early and delayed ratios for the CR and PR groups were significantly higher than those for the NC group. There were no significant differences in the retention index with respect to the tumor response. 99mTc-MIBI might be useful for evaluating the tumor chemosensitivity in patients with small cell lung cancer.
我们评估了99mTc-MIBI在小细胞肺癌患者化疗前及化疗无反应后的蓄积情况。化疗前组包括22例新诊断患者。这些患者在开始化疗前接受了99mTc-MIBI SPECT研究。化疗后，根据肿瘤大小变化，定义了三种不同的反应模式（完全缓解：CR，部分缓解：PR和无变化：NC）。化疗后组包括11例化疗无反应的患者。这些患者在化疗完成后接受了99mTc-MIBI SPECT研究。在注射99mTc-MIBI后15分钟（早期）和2小时（延迟）采集SPECT图像。采用感兴趣区技术计算早期比值、延迟比值和滞留指数。化疗前患者的早期比值和延迟比值显著高于化疗后患者。化疗前和化疗后患者的滞留指数无显著差异。在化疗前患者中，CR组和PR组的早期比值和延迟比值显著高于NC组。关于肿瘤反应，滞留指数无显著差异。99mTc-MIBI可能有助于评估小细胞肺癌患者的肿瘤化疗敏感性。
