Nagamachi S, Jinnouchi S, Flores L G, Ohnishi T, Nakahara H, Futami S, Tamura S, Watanabe K
Department of Radiology, Miyazaki Medical College.
Kaku Igaku. 1997 Jul;34(7):453-63.
We compared the detectability of 99mTc-MIBI and 201T1-chloride for primary lung cancer and mediastinal lymph node metastasis. We also analyzed the relationship between 99mTc-MIBI uptake and effectiveness of chemotherapy in patients with small cell lung cancer. The subjects were fourty-six primary lesions and 8 mediastinal metastatic lymph nodes confirmed by operation, and dual-isotope SPECT technique was performed at both 20 min and 180 min after tracer injection. A tumor to normal lung ratio on both early (ER) and delayed image (DR) and retention index (RI) were calculated. The positive rates of 99mTc-MIBI (early; 82.6%, delayed; 54.3%) were comparable to 201T1 in most primary tumor (87.0% and 84.8%). Whereas tumor smaller than 3 cm diameter was poorly visualized on both 99mTc-MIBI (25% and 0%) and 201T1 (37.5% and 37.5%). Detectabilities of metastatic mediastinal lymph nodes of 99mTc-MIBI (62.5% and 25.0%) was comparable to those of 201T1 (62.5% and 50.0%). Regarding effectiveness of chemotherapy, NC group showed lower uptake of 99mTc-MIBI and significant lower value of RI compared to PR group. We concluded that early image of 99mTc-MIBI SPECT can be helpful in detecting primary lung cancer and metastatic mediastinal lymph node. Additionary, it might be useful for predicting the effects of chemotherapy in small cell lung cancer.
我们比较了99mTc-MIBI和201T1氯化物对原发性肺癌和纵隔淋巴结转移的可检测性。我们还分析了小细胞肺癌患者99mTc-MIBI摄取与化疗疗效之间的关系。研究对象为46个经手术确诊的原发性病灶和8个纵隔转移淋巴结，在注射示踪剂后20分钟和180分钟均采用双同位素SPECT技术。计算早期（ER）和延迟图像（DR）上的肿瘤与正常肺比值以及滞留指数（RI）。在大多数原发性肿瘤中，99mTc-MIBI的阳性率（早期；82.6%，延迟；54.3%）与201T1相当（87.0%和84.8%）。而直径小于3 cm的肿瘤在99mTc-MIBI（25%和0%）和201T1（37.5%和37.5%）上均显示不佳。99mTc-MIBI对纵隔转移淋巴结的可检测性（62.5%和25.0%）与201T1相当（62.5%和50.0%）。关于化疗疗效，与PR组相比，NC组99mTc-MIBI摄取较低且RI值显著较低。我们得出结论，99mTc-MIBI SPECT的早期图像有助于检测原发性肺癌和纵隔转移淋巴结。此外，它可能有助于预测小细胞肺癌的化疗效果。
