Cenacchi G, Giovenali P, Castrioto C, Giangaspero F
Dipartimento di Scienze Radiologiche e Istocitopatologiche, Università di Bologna, Italy.
Ultrastruct Pathol. 2001 Jul-Aug;25(4):309-12. doi: 10.1080/019131201753136331.
Pituicytoma is a rare neoplasm occurring in the sellar and suprasellar regions. The tumor is currently considered to arise from the pituicyte, a specialized glial cell of the posterior lobe and the stalk of the pituitary gland. The authors describe a case of pituicytoma, focusing on the ultrastructural features. The patient was a 79-year-old woman with hypopituitarism and visual disturbances. Immunohistochemically, the tumor showed strong and diffuse positivity for vimentin, and EMA and GFAP were focally detectable. Ultrastructurally, the lesion was composed of elongated cells containing in the Golgi area aggregates of intermediate filaments in a concentric pathway (fibrous body), and secretory granules. These features intermediate between a pituicytoma and a pituitary adenoma suggest that "pituicytomas" may also arise from the specialized stromal folliculo-stellate cells of the adenohypophysis, which are able to differentiate into endocrine cells.
垂体细胞瘤是一种发生于鞍区和鞍上区域的罕见肿瘤。目前认为该肿瘤起源于垂体后叶和垂体柄的一种特殊神经胶质细胞——垂体细胞。作者描述了一例垂体细胞瘤病例，重点关注其超微结构特征。患者为一名79岁女性，有垂体功能减退和视觉障碍。免疫组化显示，肿瘤波形蛋白呈强弥漫阳性，上皮膜抗原（EMA）和胶质纤维酸性蛋白（GFAP）呈局灶性可检测。超微结构上，病变由细长细胞组成，这些细胞在高尔基区域含有呈同心排列的中间丝聚集物（纤维小体）和分泌颗粒。这些介于垂体细胞瘤和垂体腺瘤之间的特征表明，“垂体细胞瘤”也可能起源于腺垂体的特殊基质滤泡星状细胞，这些细胞能够分化为内分泌细胞。
