Sood V D, Pasricha J S, Kandhari K C
Dermatologica. 1975;150(2):86-91.
Rabbits were immunised with a fraction of normal human epidermis to produce circulating antibodies. In each experiment, half of the immunised rabbits were given a dose of the same antigen intravenously and the changes in the titres of antibodies were recorded. Doses of the antigen used in different experiments varied from 0.09 to 3.5 mg protein per rabor the first 24 h, followed by a secondary rise. Administration of corticosteroids together with the antigen intravenously could check this secondary rise in antibody titre. Repeated intravenous injections of the antigen led to severe anaphylactic reactions, while subcutaneously administered antigen produced no significant effects.
用正常人表皮的一部分对兔子进行免疫以产生循环抗体。在每个实验中，将一半免疫的兔子静脉注射一定剂量的相同抗原，并记录抗体滴度的变化。不同实验中使用的抗原剂量为每只兔子0.09至3.5毫克蛋白质。静脉注射抗原后，抗体滴度在最初24小时内下降，随后出现二次上升。静脉内同时给予皮质类固醇和抗原可抑制抗体滴度的这种二次上升。反复静脉注射抗原会导致严重的过敏反应，而皮下注射抗原则没有显著影响。
