Kalk W J, Vinik A I, Paul M, Leller P, Jackson W P
Diabetes. 1975 Sep;24(9):851-5. doi: 10.2337/diab.24.9.851.
The effects of tolbutamide infusion (1 gm. over forty minutes) on plasma pancreatic glucagon-like immunoreactivity (PGLI), serum insulin, and blood glucose were studied in six patients with chronic pancreatitis and six matched controls.asal PGLI levels were significantly higher in the patients, despite higher fasting glucose concentrations. Tolbutamide infusion had no significant effect on mean PGLI levels in controls but was associated with significant elevation in pancreatitis patients, despite higher circulating glucose levels in the latter. The data suggest that chronic calcific pancreatitis patients hypersecrete immunoreactive glucagon, possibly from a nonpancreatic source and that this immunocreactive material may be stimulated by sulfonylureas.
在6例慢性胰腺炎患者和6例匹配的对照者中，研究了静脉输注甲苯磺丁脲（40分钟内输注1克）对血浆胰高血糖素样免疫活性物质（PGLI）、血清胰岛素和血糖的影响。尽管患者空腹血糖浓度较高，但其基础PGLI水平显著更高。静脉输注甲苯磺丁脲对对照组的平均PGLI水平无显著影响，但在胰腺炎患者中却导致其显著升高，尽管后者的循环血糖水平较高。数据表明，慢性钙化性胰腺炎患者分泌免疫反应性胰高血糖素过多，可能来自非胰腺来源，且这种免疫反应性物质可能受到磺脲类药物的刺激。
