Kannan V, Nabarro J D, Cotton P B
Horm Res. 1979;11(4):203-12. doi: 10.1159/000179055.
Plasma insulin, pancreatic glucagon and immunoreactive glucagon-like polypeptide of intestinal origin (enteroglucagon) have been measured in 10 patients with chronic pancreatitis and 5 normal subjects. Basal levels and changes following oral glucose (50 g) and an intravenous infusion of arginine (25 g in 30 min) have been studied. In patients with chronic pancreatitis the plasma insulin response to oral glucose and intravenous arginine was reduced. Basal pancreatic glucagon was increased in the patients and increased further with oral glucose. During an arginine infusion the pancreatic glucagon showed a brisk early increase greater than that seen in the normal subjects. Basal enteroglucagon levels were significantly increased in chronic pancreatitis but response to orla glucose and arginine infusion were little different from those seen in the normal subjects.
对10例慢性胰腺炎患者和5名正常受试者测定了血浆胰岛素、胰高血糖素和肠道来源的免疫反应性胰高血糖素样多肽（肠高血糖素）。研究了基础水平以及口服葡萄糖（50克）和静脉输注精氨酸（30分钟内输注25克）后的变化。慢性胰腺炎患者对口服葡萄糖和静脉注射精氨酸的血浆胰岛素反应降低。患者的基础胰高血糖素升高，口服葡萄糖后进一步升高。在输注精氨酸期间，胰高血糖素早期迅速升高，且高于正常受试者。慢性胰腺炎患者的基础肠高血糖素水平显著升高，但对口服葡萄糖和精氨酸输注的反应与正常受试者所见的反应几乎没有差异。
