Gissler M, Tiitinen A
STAKES National Research and Development Centre for Welfare and Health, Helsinki University Central Hospital, Helsinki, Finland.
Acta Obstet Gynecol Scand. 2001 Oct;80(10):937-44. doi: 10.1034/j.1600-0412.2001.801011.x.
In vitro fertilization and its variants have become routine infertility treatments in industrialized countries. Our purpose is to summarize the procedures and treatment outcomes in Finland in the 1990s and to compare the results between public and private clinics.
The data came from the Finnish IVF statistics for 1992 to 1999. Most analyses were done for the years 1994 to 1998 for which identical data-collection sheets were used.
In 1999, 12 of the 19 clinics offering assisted reproductive treatments were private. The number of treatments increased from 2,331 in 1992 to 7,213 in 1999. In total 58% were performed in the private sector. Most treatments were given for women aged 30 to 39 years, but in the private sector women were up to on average two years older. Most often care was given due to tubal factor or unexplained infertility (IVF) and due to male factor or multiple causes (ICSI). The number of transferred embryos decreased during the study period, but the transfer of two embryos was still most frequent. Three out of four IVF and ICSI pregnancies, and two out of three FET pregnancies ended in a live birth. The success rates improved for IVF and for ICSI after adjustment for the number of transferred embryos, but not for FET. Small but inconsistent differences were observed in the success rates between the private and public sectors. There was noticeable variation between clinics.
The number of treatment cycles stabilized in the late 1990s. The success rates improved only slightly and the differences in outcome measures between private and public clinics were small. However, neither this nor the large clinical variation could be investigated more thoroughly without collecting individual register data.
体外受精及其衍生技术在工业化国家已成为常规的不孕治疗方法。我们的目的是总结20世纪90年代芬兰的治疗程序和治疗结果,并比较公立和私立诊所的结果。
数据来自1992年至1999年芬兰的体外受精统计数据。大多数分析针对1994年至1998年进行,这期间使用了相同的数据收集表。
1999年,提供辅助生殖治疗的19家诊所中有12家是私立的。治疗次数从1992年的2331次增加到1999年的7213次。其中58%是在私立部门进行的。大多数治疗针对30至39岁的女性,但在私立部门,女性平均年龄要大两岁左右。最常见的治疗原因是输卵管因素或不明原因不孕(体外受精)以及男性因素或多种原因(卵胞浆内单精子注射)。在研究期间,移植胚胎的数量有所减少,但移植两个胚胎仍然最为常见。四分之三的体外受精和卵胞浆内单精子注射妊娠以及三分之二的冻融胚胎移植妊娠以活产告终。在调整移植胚胎数量后,体外受精和卵胞浆内单精子注射的成功率有所提高,但冻融胚胎移植的成功率没有提高。私立和公立部门的成功率存在微小但不一致的差异。各诊所之间存在明显差异。
20世纪90年代后期治疗周期数趋于稳定。成功率仅略有提高,私立和公立诊所之间的结果指标差异较小。然而,如果不收集个体登记数据,就无法更深入地研究这一点以及较大的临床差异。