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体外受精的资源分配:一项基于全国登记的队列研究。

Resource allocation of in vitro fertilization: a nationwide register-based cohort study.

作者信息

Klemetti Reija, Gissler Mika, Sevón Tiina, Hemminki Elina

机构信息

STAKES, National Research and Development Centre for Welfare and Health, Health Services Research, Helsinki, Finland.

出版信息

BMC Health Serv Res. 2007 Dec 21;7:210. doi: 10.1186/1472-6963-7-210.

Abstract

BACKGROUND

Infertility is common and in vitro fertilization (IVF) is a widely used treatment. In IVF the need increases and the effectiveness and appropriateness decrease by age. The purpose of this study was to describe allocation of resources for IVF by women's age, socioeconomic position, area of residence and treatment sector (public vs. private) and to discuss how fairly the IVF resources are allocated in Finland.

METHODS

Women who received IVF between 1996 and 1998 (N = 9175) were identified from the reimbursement records of the Social Insurance Institution (SII). Information on IVF women's background characteristics came from the Central Population Register and the SII, on treatment costs from IVF clinics and the SII, and on births from the Medical Birth Register. The main outcome measures were success of IVF by number of cycles and treated women, expenditures per IVF cycles, per women, per live-birth, and per treatment sector, and private and public expenditures. Expenditures were estimated from health care visits and costs.

RESULTS

During a mean period of 1.5 years, older women (women aged 40 or older) received 1.4 times more IVF treatment cycles than younger women (women aged below 30). The success rate decreased by age: from 22 live births per 100 cycles among younger women to 6 per 100 among older women. The mean cost of a live birth increased by age: compared to younger women, costs per born live birth of older women were 3-fold. Calculated by population, public expenditure was allocated most to young women and women from the highest socioeconomic position. Regional differences were not remarkable.

CONCLUSION

Children of older infertile women involve more expense due to the lower success rates of IVF. Socioeconomic differences suggest unfair resource allocation in Finland.

摘要

背景

不孕症很常见,体外受精(IVF)是一种广泛使用的治疗方法。在体外受精中,随着年龄增长需求增加,而有效性和适宜性降低。本研究的目的是描述按女性年龄、社会经济地位、居住地区和治疗部门(公立与私立)分配的体外受精资源,并讨论芬兰体外受精资源的分配有多公平。

方法

从社会保险机构(SII)的报销记录中识别出1996年至1998年期间接受体外受精的女性(N = 9175)。体外受精女性的背景特征信息来自中央人口登记册和SII,治疗费用信息来自体外受精诊所和SII,出生信息来自医疗出生登记册。主要结局指标包括按周期数和治疗女性计算的体外受精成功率、每个体外受精周期、每位女性、每次活产以及每个治疗部门的支出,以及私人和公共支出。支出根据医疗就诊和费用进行估算。

结果

在平均1.5年的期间内,年龄较大的女性(40岁及以上的女性)接受的体外受精治疗周期比年龄较小的女性(30岁以下的女性)多1.4倍。成功率随年龄下降:年龄较小的女性每100个周期有22例活产,而年龄较大的女性每100个周期为6例。活产的平均成本随年龄增加:与年龄较小的女性相比,年龄较大的女性每例活产的成本是其3倍。按人口计算,公共支出分配给年轻女性和社会经济地位最高的女性最多。地区差异不显著。

结论

由于体外受精成功率较低,年龄较大的不孕女性生育孩子的费用更高。社会经济差异表明芬兰的资源分配不公平。

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