Sarna S K, Daniel E E
Gastroenterology. 1975 Sep;69(3):660-7.
The small intestinal electrical control activity (ECA) was driven by an electrical stimulus and the resultant effects on the frequency and the phase relationships of control waves recorded. The small intestinal ECA can be driven from all sites from which it could be recorded. The mean maximum driven frequency (MDF) was the highest near the pylorus and it decreased distally, but at any given site it was the same before and after dividing the small intestine into small segments. The length of the frequency plateau decreased and phase lag per cm increased with an increase in plateau frequency. The direction of phase lag was orad proximal to a stimulation site and aborad distal to it. Intravenous atropine (up to 100 mug per kg) or reserpinization of dogs before an experiment had no effect on the MDF in the frequency plateau region. The study confirms the validity of an array of bidirectionally coupled relaxation oscillators as a model of small intestinal ECA and shows that the frequency and the phase relationship of small intestinal control waves can be altered by electrical stimulation. The study also points out some differences between the small intestinal and gastric ECA's at the cellular level.
小肠电控制活动（ECA）由电刺激驱动，并记录由此对控制波的频率和相位关系产生的影响。小肠ECA可以从能够记录到它的所有部位被驱动。平均最大驱动频率（MDF）在幽门附近最高，向远端降低，但在任何给定部位，将小肠分成小段前后该频率是相同的。频率平台期的长度随平台频率增加而缩短，每厘米的相位滞后增加。相位滞后的方向在刺激部位近端是向口腔方向，在其远端是向肛门方向。实验前静脉注射阿托品（高达每千克100微克）或使狗利血平化对频率平台期区域的MDF没有影响。该研究证实了一系列双向耦合弛豫振荡器作为小肠ECA模型的有效性，并表明小肠控制波的频率和相位关系可通过电刺激改变。该研究还指出了小肠和胃ECA在细胞水平上的一些差异。
