非融合诱导型和融合诱导型1型人类免疫缺陷病毒变体对不同CD4(+) - T细胞亚群的细胞病变效应仅由共受体表达决定。
Cytopathic effects of non-syncytium-inducing and syncytium-inducing human immunodeficiency virus type 1 variants on different CD4(+)-T-cell subsets are determined only by coreceptor expression.
作者信息
Kwa D, Vingerhoed J, Boeser-Nunnink B, Broersen S, Schuitemaker H
机构信息
Department of Clinical Viro-Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
出版信息
J Virol. 2001 Nov;75(21):10455-9. doi: 10.1128/JVI.75.21.10455-10459.2001.
Abstract
In peripheral blood mononuclear cells, syncytium-inducing (SI) human immunodeficiency virus type 1 (HIV-1) infected and depleted all CD4(+) T cells, including naive T cells. Non-SI HIV-1 infected and depleted only the CCR5-expressing T-cell subset. This may explain the accelerated CD4 cell loss after SI conversion in vivo.
摘要
在外周血单个核细胞中，合胞体诱导型（SI）1型人类免疫缺陷病毒（HIV-1）感染并耗尽了所有CD4(+) T细胞，包括初始T细胞。非SI HIV-1仅感染并耗尽表达CCR5的T细胞亚群。这可能解释了体内SI转化后CD4细胞加速丢失的现象。
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