糖原合成酶激酶3的复兴
The renaissance of GSK3.
作者信息
Cohen P, Frame S
机构信息
MRC Protein Phosphorylation Unit and Division of Signal Transduction Therapy, School of Life Sciences, University of Dundee, DD1 5EH, Scotland, UK.
出版信息
Nat Rev Mol Cell Biol. 2001 Oct;2(10):769-76. doi: 10.1038/35096075.
DOI:10.1038/35096075
PMID:11584304
Abstract
Glycogen synthase kinase 3 (GSK3) was initially described as a key enzyme involved in glycogen metabolism, but is now known to regulate a diverse array of cell functions. The study of the substrate specificity and regulation of GSK3 activity has been important in the quest for therapeutic intervention.
摘要
糖原合酶激酶3（GSK3）最初被描述为参与糖原代谢的关键酶，但现在已知它能调节多种细胞功能。在寻求治疗干预措施的过程中，对GSK3活性的底物特异性和调节的研究一直很重要。
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