Woodgett J R
Division of Cell and Molecular Biology, Ontario Cancer Institute, Toronto, Canada.
Semin Cancer Biol. 1994 Aug;5(4):269-75.
Glycogen synthase kinase-3 is a 'black sheep' among protein kinases. Although its name suggests a primary function in intermediary metabolism, its scope is far more diverse as indicated by both genetic and biochemical evidence. Over the past five years the enzyme has emerged as an important component of transduction pathways ultimately regulating cell fate and differentiation. The molecular mechanisms underlying these functions are only just being unraveled but point to a novel mode of cellular regulation conserved in all eukaryotes.
糖原合酶激酶-3是蛋白激酶中的“异类”。尽管其名称表明它在中间代谢中具有主要功能，但遗传和生化证据均显示，其作用范围要广泛得多。在过去五年中，该酶已成为转导通路的重要组成部分，最终调控细胞命运和分化。这些功能背后的分子机制才刚刚被揭示，但表明在所有真核生物中都存在一种保守的新型细胞调节模式。
