阿尔茨海默病的转基因小鼠模型

Transgenic mouse models of Alzheimer's disease.

作者信息

Hock B J, Lamb B T

机构信息

Dept of Genetics, Case Western Reserve University, University Hospitals of Cleveland, 10900 Euclid Avenue, Cleveland, OH 44106-4955, USA.

出版信息

Trends Genet. 2001 Oct;17(10):S7-12. doi: 10.1016/s0168-9525(01)02449-0.

DOI:10.1016/s0168-9525(01)02449-0

PMID:11585670

Abstract

Recent advances in the understanding of the genetic basis of Alzheimer's disease have enabled the production of transgenic mouse models of the disease. Utilizing both cDNA- and genomic-based approaches, these mouse models for Alzheimer's disease have already provided valuable insights into the pathogenesis of the disease and potential therapeutic interventions.

摘要

在对阿尔茨海默病遗传基础的理解方面取得的最新进展，使得能够构建该疾病的转基因小鼠模型。利用基于互补DNA（cDNA）和基因组的方法，这些阿尔茨海默病小鼠模型已经为该疾病的发病机制和潜在治疗干预提供了有价值的见解。