Kapu S D, Ngwai Y B, Kayode O, Akah P A, Wambebe C, Gamaniel K
Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development, Idu Industrial Area, P.M.B. 21, Garki, Abuja, Nigeria.
J Ethnopharmacol. 2001 Nov;78(1):7-13. doi: 10.1016/s0378-8741(01)00308-7.
The anti-inflammatory, anti-lymphocytic and analgesic properties of Crinum giganteum, a popular herb used for the management of asthma and other respiratory disorders was investigated in rats and mice. The extract dose-dependently produced significant (P<0.05) inhibition of formalin induced pain in rats. It also demonstrated significant (P<0.01) inhibition of abdominal constriction induced with 0.75% v/v acetic acid in mice. On the cotton pellet induced granulomatous tissue formation in rats, the extract significantly (P<0.05) decreased the weight. However, no significant inhibition was observed in the egg albumin-induced inflammation in rats. Oral administration of this extract in rats for 14 days significantly affected (P<0.05) the total leukocyte count and the overall percentage lymphocytes. The intraperitoneal and per oral LD(50) were 627+/-5.8mg/kg and 1486+/-18.9 mg/kg in mice and 520+/-10.2mg/kg and 1023+/-4.3 mg/kg in rats, respectively. Preliminary phytochemical analysis of the extract indicates the presence of tannins. These results therefore indicate that C. giganteum bulb contains biologically active principles, which have potentials for the treatment of inflammatory processes.
对一种用于治疗哮喘和其他呼吸系统疾病的常用草药巨型文殊兰的抗炎、抗淋巴细胞和镇痛特性在大鼠和小鼠中进行了研究。提取物剂量依赖性地对大鼠福尔马林诱导的疼痛产生显著（P<0.05）抑制作用。它还对小鼠0.75% v/v乙酸诱导的腹部收缩表现出显著（P<0.01）抑制作用。在大鼠棉球诱导的肉芽肿组织形成实验中，提取物显著（P<0.05）降低了重量。然而，在大鼠蛋清诱导的炎症中未观察到显著抑制作用。在大鼠中口服该提取物14天对总白细胞计数和淋巴细胞总体百分比有显著（P<0.05）影响。小鼠腹腔注射和口服的半数致死量（LD50）分别为627±5.8mg/kg和1486±18.9mg/kg，大鼠分别为520±10.2mg/kg和1023±4.3mg/kg。提取物的初步植物化学分析表明存在单宁。因此，这些结果表明巨型文殊兰鳞茎含有生物活性成分，具有治疗炎症过程的潜力。
