Olajide O A, Awe S O, Makinde J M, Ekhelar A I, Olusola A, Morebise O, Okpako D T
Department of Pharmacology, Faculty of Pharmacy, Obafemi Awolowo University, Ile-Ife, Nigeria.
J Ethnopharmacol. 2000 Jul;71(1-2):179-86. doi: 10.1016/s0378-8741(99)00200-7.
The methanol extract of the stem bark of Alstonia boonei was investigated for anti-inflammatory property. The analgesic and antipyretic properties of the extract was also evaluated. The extract caused a significant (P<0.05) inhibition of the carrageenan-induced paw oedema, cotton pellet granuloma, and exhibited an anti-arthritic activity in rats. Vascular permeability induced by acetic acid in the peritoneum of mice was also inhibited. The extract also produced marked analgesic activity by reduction of writhings induced by acetic acid, as well as the early and late phases of paw licking in mice. A significant (P<0.05) reduction in hyperpyrexia in mice was also produced by the extract. This study has established anti-inflammatory, analgesic and antipyretic activities of the stem bark of A. boonei.
对布氏鸡骨常山茎皮的甲醇提取物进行了抗炎特性研究。还评估了该提取物的镇痛和解热特性。该提取物对角叉菜胶诱导的爪肿胀、棉球肉芽肿有显著（P<0.05）抑制作用，并在大鼠中表现出抗关节炎活性。对小鼠腹膜中由乙酸诱导的血管通透性也有抑制作用。该提取物还通过减少乙酸诱导的扭体反应以及小鼠舔爪的早期和晚期阶段产生了显著的镇痛活性。该提取物还使小鼠的高热显著（P<0.05）降低。本研究证实了布氏鸡骨常山茎皮具有抗炎、镇痛和解热活性。
