Cotlier E, Baskin M, Kresca L
Invest Ophthalmol. 1975 Sep;14(9):697-701.
Lenses incubated for 24 or 63 hours in media containing either lysophosphatidyl choline or phospholipase A gained Na+ ions and water. Electrolyte imbalances and damage to lens fiber membranes occurred at lysophosphatidyl choline and phospholipase A concentrations of 7.5 mug per milliliter and 0.25 mug per milliliter, respectively. Intravitreal injection of 250 mug of lysophosphatidyl choline or 0.4 mug of phospholipase A induced posterior subcapsular cataracts which progressed to maturity only in the latter instance. This is the first demonstration of the cataractogenic effects of a naturally occurring aqueous humor phospholipid or its generating enzyme.
在含有溶血磷脂酰胆碱或磷脂酶A的培养基中孵育24或63小时的晶状体获得了钠离子和水分。溶血磷脂酰胆碱和磷脂酶A的浓度分别为每毫升7.5微克和每毫升0.25微克时，会出现电解质失衡和晶状体纤维膜损伤。玻璃体内注射250微克溶血磷脂酰胆碱或0.4微克磷脂酶A会诱发后囊下白内障，只有在后一种情况下白内障才会发展至成熟。这是首次证明天然存在的房水磷脂或其生成酶具有致白内障作用。
