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1
Lysophosphatidyl choline in the aqueous humour during ocular inflammation.眼部炎症期间房水中的溶血磷脂酰胆碱。
Br J Ophthalmol. 1979 Nov;63(11):768-70. doi: 10.1136/bjo.63.11.768.
2
Cataracts in Uveitis.葡萄膜炎中的白内障
Trans Ophthalmol Soc U K (1962). 1982;102 Pt 3:390-4.
3
Lysophosphatidyl choline and cataracts in uveitis.葡萄膜炎中的溶血磷脂酰胆碱与白内障
Arch Ophthalmol. 1976 Jul;94(7):1159-62. doi: 10.1001/archopht.1976.03910040071013.
4
[Phospholipase A and lysophosphatidylcholine in the pathogenesis of "permeability cataracts" (author's transl)].磷脂酶A和溶血磷脂酰胆碱在“渗透性白内障”发病机制中的作用（作者译）
Klin Monbl Augenheilkd. 1977 Mar;170(3):433-6.
5
Serum proteins neutralize the toxic effect of lysophosphatidyl choline.血清蛋白可中和溶血磷脂酰胆碱的毒性作用。
Curr Eye Res. 1982;2(9):621-4. doi: 10.3109/02713688208996363.
6
Immunobiology of the lens. Experimental studies on lens cation and protein permeability in the presence of various antigen-antibody reactions.晶状体的免疫生物学。关于在各种抗原 - 抗体反应存在下晶状体阳离子和蛋白质通透性的实验研究。
Folia Allergol (Roma). 1971 Nov-Dec;18(6):496-510.
7
Effects of lysophosphatidyl choline and phospholipase A on the lens.溶血磷脂酰胆碱和磷脂酶A对晶状体的影响。
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8
The proteins of the aqueous humour.房水的蛋白质
Doc Ophthalmol. 1982 Nov 1;53(3):193-248. doi: 10.1007/BF00140422.
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Analysis of lipid peroxidation and electron microscopic survey of maturation stages during human cataractogenesis: pharmacokinetic assay of Can-C N-acetylcarnosine prodrug lubricant eye drops for cataract prevention.人类白内障形成过程中脂质过氧化分析及成熟阶段的电子显微镜观察：用于预防白内障的Can-C N-乙酰肉碱前药润滑眼药水的药代动力学测定。
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Immunopathology of the lens. I 86Rb efflux and protein leakage from normal lenses exposed to unrelated antigen-antibody interactions.晶状体的免疫病理学。I. 暴露于无关抗原-抗体相互作用的正常晶状体的⁸⁶Rb外流和蛋白质渗漏。
Ophthalmologica. 1977;176(3):164-9. doi: 10.1159/000308710.

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本文引用的文献

1
Phosphorus assay in column chromatography.柱色谱法中的磷测定
J Biol Chem. 1959 Mar;234(3):466-8.
2
Immunization of rabbits with autologous lens homogenates.用自体晶状体匀浆对兔子进行免疫接种。
Arch Ophthalmol. 1965 Oct;74(4):528-31. doi: 10.1001/archopht.1965.00970040530017.
3
Anti-uveal and anti-lens antibodies in uveitis and their significance.葡萄膜炎中的抗葡萄膜和抗晶状体抗体及其意义。
Exp Eye Res. 1968 Oct;7(4):561-9. doi: 10.1016/s0014-4835(68)80010-7.
4
Influence of prostaglandins on cation movement in the lens.前列腺素对晶状体中阳离子移动的影响。
Exp Eye Res. 1973 May 24;15(6):767-78. doi: 10.1016/0014-4835(73)90009-2.
5
Human cellular immunity to lens leukocyte migration inhibition by lens protein.人类对晶状体蛋白所致晶状体白细胞迁移抑制的细胞免疫。
Arch Intern Med. 1974 Oct;134(4):684-8.
6
Quantitation of alpha crystallin in human aqueous humor by radioimmunoassay.用放射免疫分析法对人房水中α晶状体蛋白进行定量分析。
Acta Ophthalmol (Copenh). 1974;52(1):161-71. doi: 10.1111/j.1755-3768.1974.tb00363.x.
7
Phospholipid composition of aqueous humor, plasma and lens in normal and alloxan diabetic rabbits.正常及四氧嘧啶糖尿病兔房水、血浆和晶状体的磷脂成分
Exp Eye Res. 1972 Mar;13(2):120-5. doi: 10.1016/0014-4835(72)90024-3.
8
Effects of lysophosphatidyl choline and phospholipase A on the lens.溶血磷脂酰胆碱和磷脂酶A对晶状体的影响。
Invest Ophthalmol. 1975 Sep;14(9):697-701.
9
Release of protein and cations from the lens in the presence of different antigen-antibody interactions.在不同抗原-抗体相互作用存在的情况下，晶状体中蛋白质和阳离子的释放。
Mod Probl Ophthalmol. 1976;16:80-94.
10
Lysophosphatidyl choline and cataracts in uveitis.葡萄膜炎中的溶血磷脂酰胆碱与白内障
Arch Ophthalmol. 1976 Jul;94(7):1159-62. doi: 10.1001/archopht.1976.03910040071013.

眼部炎症期间房水中的溶血磷脂酰胆碱。

Lysophosphatidyl choline in the aqueous humour during ocular inflammation.

作者信息

Secchi A G, Fregona I, D'Ermo F

出版信息

Br J Ophthalmol. 1979 Nov;63(11):768-70. doi: 10.1136/bjo.63.11.768.

DOI:10.1136/bjo.63.11.768
PMID:508693
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1043615/
Abstract

Phospholipase A and lysophosphatidyl choline (LPC) have been shown to induce significant changes in the lens permeability in vitro to cations and soluble proteins. During uveal inflammation, in various experimental models and in man as well, the levels of LPC in the aqueous humour have been shown to reach values which are harmful to the lens in vitro. In addition, a phospholipase is thought to be activated during the antigen + antibody + complement sequence. The possible significance of these findings is discussed in relation to the pathogenesis of complicated cataracts in uveitis and the possible role of the lens as a source of autoantigens in recurrent uveitis.

摘要

磷脂酶A和溶血磷脂酰胆碱（LPC）已被证明在体外可诱导晶状体对阳离子和可溶性蛋白质的通透性发生显著变化。在葡萄膜炎症期间，在各种实验模型以及人体中，房水中LPC的水平已被证明会达到在体外对晶状体有害的值。此外，人们认为在抗原+抗体+补体反应序列中磷脂酶会被激活。结合葡萄膜炎并发白内障的发病机制以及晶状体作为复发性葡萄膜炎自身抗原来源的可能作用，对这些发现的潜在意义进行了讨论。