眼部炎症期间房水中的溶血磷脂酰胆碱。
Lysophosphatidyl choline in the aqueous humour during ocular inflammation.
作者信息
Secchi A G, Fregona I, D'Ermo F
出版信息
Br J Ophthalmol. 1979 Nov;63(11):768-70. doi: 10.1136/bjo.63.11.768.
Abstract
Phospholipase A and lysophosphatidyl choline (LPC) have been shown to induce significant changes in the lens permeability in vitro to cations and soluble proteins. During uveal inflammation, in various experimental models and in man as well, the levels of LPC in the aqueous humour have been shown to reach values which are harmful to the lens in vitro. In addition, a phospholipase is thought to be activated during the antigen + antibody + complement sequence. The possible significance of these findings is discussed in relation to the pathogenesis of complicated cataracts in uveitis and the possible role of the lens as a source of autoantigens in recurrent uveitis.
摘要
磷脂酶A和溶血磷脂酰胆碱（LPC）已被证明在体外可诱导晶状体对阳离子和可溶性蛋白质的通透性发生显著变化。在葡萄膜炎症期间，在各种实验模型以及人体中，房水中LPC的水平已被证明会达到在体外对晶状体有害的值。此外，人们认为在抗原+抗体+补体反应序列中磷脂酶会被激活。结合葡萄膜炎并发白内障的发病机制以及晶状体作为复发性葡萄膜炎自身抗原来源的可能作用，对这些发现的潜在意义进行了讨论。
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本文引用的文献
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Anti-uveal and anti-lens antibodies in uveitis and their significance.葡萄膜炎中的抗葡萄膜和抗晶状体抗体及其意义。
Exp Eye Res. 1968 Oct;7(4):561-9. doi: 10.1016/s0014-4835(68)80010-7.
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Influence of prostaglandins on cation movement in the lens.前列腺素对晶状体中阳离子移动的影响。
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