Ayas N T, Epstein L J, Lieberman S L, Tun C G, Larkin E K, Brown R, Garshick E
Pulmonary and Critical Care Medicine Section, VA Boston Healthcare System, West Roxbury, Massachusetts 02132, USA.
J Spinal Cord Med. 2001 Spring;24(1):30-4. doi: 10.1080/10790268.2001.11753552.
Predictors of loud snoring were examined in a cohort of 197 persons with chronic spinal cord injury (SCI) recruited by advertisement and from a Veterans Affairs Medical Center SCI Service.
Data were collected on age, marital status, antispasticity medications, duration of injury, level and completeness of injury, stature, and weight. Body mass index (BMI) was calculated for all participants. A health questionnaire was used to collect data on snoring and respiratory history. Habitual snorers were defined as those who reported loud snoring more than 1 night per week.
The mean age (+/- SD) was 51.2 +/- 14.8 years, and 84 of 197 (42.6%) were habitual snorers. The most obese research subjects, regardless of antispasticity medication use, were more likely to report snoring, but the risk of snoring was greatest among subjects who were obese and used antispasticity medication. Subjects who used antispasticity medication and had a BMI above the median (> or = 25.3 kg/m2) had a 7-fold risk of reporting snoring compared with subjects below the median who did not use antispasticity medication (P = .001). The greatest risk occurred in those who used diazepam alone or baclofen and diazepam together and had a BMI at or above the median. Subjects who used these medications and had a BMI below the median did not have a significantly increased risk. Neurological motor completeness, level of injury, age, and years since injury were not significant predictors of snoring.
Because snoring is a marker for obstructive sleep apnea (OSA), the data suggest that in obese individuals with SCI, the use of antispasticity medications may be a risk factor for OSA.
通过广告招募并从退伍军人事务医疗中心脊髓损伤(SCI)服务部选取了197名慢性脊髓损伤患者,对大声打鼾的预测因素进行了研究。
收集了年龄、婚姻状况、抗痉挛药物使用情况、损伤持续时间、损伤水平和完整性、身高和体重等数据。为所有参与者计算体重指数(BMI)。使用健康问卷收集打鼾和呼吸病史数据。习惯性打鼾者定义为每周大声打鼾超过1晚的人。
平均年龄(±标准差)为51.2±14.8岁,197人中有84人(42.6%)为习惯性打鼾者。无论是否使用抗痉挛药物,最肥胖的研究对象更有可能报告打鼾,但肥胖且使用抗痉挛药物的受试者打鼾风险最大。使用抗痉挛药物且BMI高于中位数(≥25.3kg/m²)的受试者报告打鼾的风险是未使用抗痉挛药物且BMI低于中位数的受试者的7倍(P = 0.001)。风险最高的是单独使用地西泮或同时使用巴氯芬和地西泮且BMI处于或高于中位数的人。使用这些药物且BMI低于中位数的受试者风险没有显著增加。神经运动完整性、损伤水平、年龄和受伤年限不是打鼾的显著预测因素。
由于打鼾是阻塞性睡眠呼吸暂停(OSA)的一个标志,数据表明,在肥胖的SCI患者中,使用抗痉挛药物可能是OSA的一个危险因素。