Sander K, Scheich H
Leibniz Institute for Neurobiology, Brenneckestrasse 6, 39118, Magdeburg, Germany.
Brain Res Cogn Brain Res. 2001 Oct;12(2):181-98. doi: 10.1016/s0926-6410(01)00045-3.
Adequate behavioral responses to socially relevant stimuli are often impaired after lesions of the amygdala. Such lesions concern especially the recognition of facial and sometimes of vocal expression of emotions. Using low-noise functional magnetic resonance imaging (fMRI), we investigated in which way the amygdala, auditory cortex and insula are involved in the processing of affective nonverbal vocalizations (Laughing and Crying) in healthy humans. The same samples of male and female Laughing and Crying were presented in different experimental conditions: Simply listening to the stimuli, self-induction of the corresponding emotions while listening, and detection of artificial pitch shifts in the same stimuli. All conditions activated the amygdala similarly and bilaterally, whereby the amount of activation was larger in the right amygdala. The auditory cortex was more strongly activated by Laughing than by Crying with a slight right-hemisphere advantage for Laughing, both likely due to acoustic stimulus features. The insula was bilaterally activated in all conditions. The mean signal intensity change with stimulation was much larger in the amygdala than in auditory cortex and insula. The amygdala results seem to be in accordance with the right-hemisphere hypothesis of emotion processing which may not be applicable as strongly to the level of auditory cortex or insula.
杏仁核受损后，对社会相关刺激的适当行为反应常常受损。此类损伤尤其影响对面部表情以及有时对声音情绪表达的识别。我们使用低噪声功能磁共振成像（fMRI），研究了在健康人类中杏仁核、听觉皮层和脑岛以何种方式参与情感性非言语发声（笑和哭）的处理。在不同实验条件下呈现相同的男性和女性笑与哭的样本：单纯聆听刺激、聆听时自我诱发相应情绪以及检测相同刺激中的人工音高变化。所有条件均类似地双侧激活杏仁核，其中右侧杏仁核的激活量更大。与哭相比，笑对听觉皮层的激活更强，且笑在右半球有轻微优势，这两者可能都归因于声学刺激特征。脑岛在所有条件下均双侧激活。杏仁核中刺激引起的平均信号强度变化远大于听觉皮层和脑岛。杏仁核的结果似乎符合情绪处理的右半球假说，但该假说可能对听觉皮层或脑岛层面的适用性没那么强。
