病原体的适应性突变、突变型DNA聚合酶及遗传变化策略。
Adaptive mutations, mutator DNA polymerases and genetic change strategies of pathogens.
作者信息
McKenzie G J, Rosenberg S M
机构信息
Department of Molecular Genetics, Baylor College of Medicine, One Baylor Plaza, Room S809 Mail Stop 225, Houston, TX 77030-3411, USA.
出版信息
Curr Opin Microbiol. 2001 Oct;4(5):586-94. doi: 10.1016/s1369-5274(00)00255-1.
"Adaptive" or "stationary-phase" mutation is a collection of stress responses promoting mutations, some of which are advantageous. In 2000 and 2001, in Escherichia coli, adaptive gene amplification was documented, and a parallel adaptive point-mutation mechanism was linked to the error-prone DNA polymerase, DinB (pol IV). We suggest that DinB homologues may contribute to adaptive strategies of pathogens, including antigenic variation.
“适应性”或“稳定期”突变是一系列促进突变的应激反应，其中一些是有利的。2000年和2001年，在大肠杆菌中记录了适应性基因扩增，并且一种平行的适应性点突变机制与易错DNA聚合酶DinB（pol IV）相关联。我们认为DinB同源物可能有助于病原体的适应性策略，包括抗原变异。
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