Nicewarner-Pena S R, Freeman R G, Reiss B D, He L, Pena D J, Walton I D, Cromer R, Keating C D, Natan M J
Department of Chemistry, Pennsylvania State University, 152 Davey Laboratory, University Park, PA 16802, USA., SurroMed Inc., 2375 Garcia Avenue, Mountain View, CA 94043, USA.
Science. 2001 Oct 5;294(5540):137-41. doi: 10.1126/science.294.5540.137.
We synthesized multimetal microrods intrinsically encoded with submicrometer stripes. Complex striping patterns are readily prepared by sequential electrochemical deposition of metal ions into templates with uniformly sized pores. The differential reflectivity of adjacent stripes enables identification of the striping patterns by conventional light microscopy. This readout mechanism does not interfere with the use of fluorescence for detection of analytes bound to particles by affinity capture, as demonstrated by DNA and protein bioassays.
我们合成了具有亚微米条纹固有编码的多金属微棒。通过将金属离子顺序电化学沉积到具有均匀尺寸孔的模板中，可以轻松制备复杂的条纹图案。相邻条纹的差分反射率使得能够通过传统光学显微镜识别条纹图案。如DNA和蛋白质生物测定所示，这种读出机制不会干扰使用荧光来检测通过亲和捕获与颗粒结合的分析物。
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