Yates A, Chan C C, Callard R E, George A J, Stark J
CoMPLEX, University College London, UK.
Brief Bioinform. 2001 Sep;2(3):245-57. doi: 10.1093/bib/2.3.245.
Like most other fields in biology, immunology has been revolutionised by the techniques of molecular biology and the resulting explosion in available experimental data. It is argued that efforts to integrate the data to gain insight into how various subsystems in the immune system interact and function require mathematical modelling and computer simulation in close collaboration with experimentalists. This paper illustrates some of the techniques available for modelling immune systems, and highlights the issues that should be borne in mind by anyone starting down the modelling path.
与生物学中的大多数其他领域一样,免疫学因分子生物学技术以及由此带来的可用实验数据的激增而发生了变革。有人认为,要整合这些数据以深入了解免疫系统中各个子系统如何相互作用和发挥功能,就需要与实验人员密切合作进行数学建模和计算机模拟。本文阐述了一些可用于免疫系统建模的技术,并着重指出了任何刚开始涉足建模领域的人都应牢记的问题。